From executive producers Paul Attanasio, Katie Jacobs, David Shore, and Bryan Singer comes a new take on mystery, where the villain is a medical malady and the hero is an irreverent, controversial doctor who trusts no one, least of all his patients. Dr. Gregory House (Hugh Laurie) is devoid of bedside manner and wouldn't even talk to his patients if he could get away with it. Dealing with his own constant physical pain, he uses a cane that seems to punctuate his acerbic, brutally honest demeanor. While his behavior can border on antisocial, House is a maverick physician whose unconventional thinking and flawless instincts have afforded him a great deal of respect. An infectious disease specialist, he's a brilliant diagnostician who loves the challenges of the medical puzzles he must solve in order to save lives.
Episode 01 - Alone
An office building collapses and House must race against the clock to diagnose Megan, a young woman who survived the disaster but can only communicate through blinking. However, House is without a team after Foreman and Cameron quit and the firing of Chase, so he's forced to talk through his ideas with the hospital janitor. But when Megan's condition worsens, House is pressured to hire a new team. Through reluctant to do so, House begins to realize diagnosing patients by himself is not as easy as he thought.
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House reluctantly agrees to interview potential new team members and does so in his own way. He calls in all 40 applicants and places each of them in a Darwinian trial period. As he tests them, and fires some along the way, he is approached by Greta, a NASA training program candidate, who is having neurological issues and begs House to help her in private so she can be accepted into the training program.
House takes Greta's case to his applicants, pitting them against one another as they compete to come up with an accurate diagnosis. Later, House is shocked when he sees what appears to be Cameron, Chase and Foreman in the hospital hallways.
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The candidates are now two teams of five women and five men, competing on diagnosing and treating a wheelchair-bound man. Meanwhile House does experiments on himself to test what happens after death, and Foreman, at another hospital, is treating his team in a House-like manner.
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The team treats a patient who not only claims to see the dead, but she communicates with them and knows things about them she normally couldn't find out.
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The team takes on the case of a man who collapsed while being mugged. When the man complains of new symptoms that do not fit his initial admission profile, the team suspects he is a hypochondriac. As Mr. X continues to fall ill with symptoms unrelated to his neurological disorder, Foreman and the remaining six fellows are assigned to keep watch, and are bemused as they see their own behavioral idiosyncrasies reflected through him. As they attempt to diagnose this human chameleon, they seem to learn more about themselves than their patient, whose true identity is a mystery. Meanwhile, Cameron and Chase keep a running pool on whom House might cut next from the team of candidates, and Foreman engages in a power struggle with House and Cuddy.
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Based on practically no information and no medical history about a mystery patient sent by the CIA, House is using some unorthodox methods to diagnose and treat him. Meanwhile the remaining candidates are questioning Foreman's judgment.
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A film crew and the candidates are following around House distracting him while he is trying to diagnose a teenager who suffers from a heart attack prior to a serious plastic surgery.
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House treats a magician who had a heart attack during an illusion. House doesn't like magicians and figures the guy screwed up, but the tests prove otherwise. Meanwhile, the fellows participate in House's newest game: the winner gets immunity and the chance to pick two other fellows, and House will fire one of them.
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When Cuddy puts the pressure on House to choose the final members of his team, House deliberately assigns the candidates to a particularly challenging case an uncooperative, over-the-hill former punk rock star with a history of drug abuse and civil disobedience. House informs the candidates their potential future depends on correctly diagnosing the patient. As the candidates race to find out if the patient is ailing due to drug abuse, an underlying disease or an unknown condition, House keeps a running tally of their efforts, making a few arbitrary point deductions along the way. Meanwhile, Wilson informs a former patient whom he had previously diagnosed with terminal cancer that he is going to live, and the news throws a wrench in the man's carpe-diem lifestyle
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